在患有乳病的患者中,关节疾病的发病率:系统性审查和元分析
Dimitri Poddighe1, Gulsamal Zhubanova2, Dinara Galiyeva2
1College of Health Sciences, VinUniversity, Gia Lam District, Hanoi 10000, Vietnam.
关节不适是患有乳病 (CD) 的患者常见的肠外表现. 这项元分析发现,在没有类风湿性疾病的CD患者中,患病率为10.7%,这凸显了需要提高认识的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 关节的投诉被认为是病 (CD) 的潜在肠外表现.
- 结核病患者,特别是那些没有类风湿性并发症的患者中关节问题的患病率需要进一步调查.
- 了解这种关联对于全面的患者护理至关重要.
研究的目的:
- 为了估计诊断为患有乳病的患者的关节疾病的患病率.
- 通过元分析,综合现有关于CD联合表现的证据.
主要方法:
- 在主要数据库 (Medline,Embase,Cochrane,Web of Science) 中对1990年至2024年间发表的研究进行了系统的文献搜索.
- 对27项研究进行了元分析,其中包括6901名患有CD的患者,使用随机效应模型.
- 通过Joanna Briggs研究所的批判性评估工具评估了研究质量,并评估了出版偏差.
主要成果:
- 在没有风湿并发症的CD患者中,关节疾病的综合患病率为10.7% (95% CI:6.9-15.1).
- 超回归分析没有显示关联联合投诉的患病率和患者的人口统计学或临床特征.
- 在6901名患者中,530人报告了关节疾病.
结论:
- 关节疼痛是显著的,非罕见的表现,在缺乏特定的类风湿性诊断的乳病患者.
- 提高对CD关节疾病的临床意识对于提高诊断准确性和患者管理至关重要.
- 这一发现强调了在对乳病的整体评估中考虑类风湿症状的重要性.
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