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预测HFpEF老年患者的认知障碍:开发一个简单的临床风险评分

Sergiu-Florin Arnautu^1,2, Brenda-Cristiana Bernad^2,3,4, Istvan Gyalai Korpos^2,5

¹Centre for Cognitive Research in Neuropsychiatric Pathology (NeuroPsy-Cog), Department of Neurosciences, "Victor Babes" University of Medicine and Pharmacy, E. Murgu Sq., no.2, 300041 Timisoara, Romania.

Journal of clinical medicine

|June 13, 2025

概括

认知障碍在老年心力衰竭患者中很常见,这些患者有保存的喷射分数 (HFpEF). 一个新的风险评分可以识别有风险的患者,有助于早期干预以获得更好的结果.

科学领域:

心脏病学心脏病学
神经学神经学
老年病的医生老年病的医生

背景情况:

认知障碍是老年心力衰竭患者常见的,未被认可的并发症,其中包括心力衰竭与保留射出分数 (HFpEF).
这种情况导致结果差,并使这种脆弱人群的疾病管理复杂化.

研究的目的:

确定罗马尼亚西部老年HFpEF患者认知障碍的危险因素.
开发一个实际的,基于点的风险评分,用于诊断认知功能障碍的临床使用.

主要方法:

326名年龄≥65岁的HFpEF患者的横截面分析.
使用迷你精神状态检查-2 (MMSE-2) 评估认知状态;显著损伤定义为MMSE-2得分<24.
多变量逻辑回归确定了认知功能障碍的独立预测因素.

主要成果:

糖尿病,先前的中风/TIA,动脉疾病,高NT-proBNP和降低的eGFR独立地与认知障碍有关.
较高的12-KCCQ评分和对心房的抗凝剂治疗与较低的风险有关.
开发的基于点的风险评分显示出强烈的区分能力 (AUC=0.84),具有≥2点的门,以75%的灵敏度和83%的特异性识别损伤.

结论:

综合心血管和认知评估对于老年HFpEF患者至关重要.
开发的风险评分是用于早期识别认知功能障碍的务实工具.
及时干预和预防策略可以通过这种风险评分得到信息.

关键词:

认知障碍是一种认知障碍.认知风险评分认知风险评分年长的病人,老年患者.心力衰竭与保存的喷射分数的心脏衰竭

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