胎盘线粒体功能障碍对围产期不良结果的作用:系统性审查
Charalampos Voros1, Sofoklis Stavros2, Ioakeim Sapantzoglou1
11st Department of Obstetrics and Gynecology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Journal of clinical medicine
|June 13, 2025
概括
胎盘线粒体功能障碍与先兆子和生长限制等出生结果不佳有关. 关键指标包括减少mtDNA拷贝数和增加氧化应激,这表明对母胎健康的治疗目标.
科学领域:
- 围产儿医学 围产儿医学
- 线粒体生物学 线粒体生物学
- 生殖健康 生殖健康
背景情况:
- 线粒体对于胎盘功能至关重要,调节新陈代谢,氧化平衡和亡.
- 胎盘线粒体功能障碍越来越多地涉及到不良周产期结果,如子宫前,子宫内生长限制 (IUGR),早产和死胎.
- 缺乏关于这种联系的人类研究的全面系统审查.
研究的目的:
- 系统地审查和巩固人类研究证据关于胎盘线粒体功能障碍和不良出生结果之间的关联.
- 在各种不良周产期结果中识别线粒体功能障碍的共同分子特征.
- 探索潜在的治疗和预测生物标志物途径.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索.
- 包括研究胎盘线粒体特征的人类研究 (例如,mtDNA复制数,ATP生产,氧化应激) 和不良妊娠结果.
- 由于方法异质性,叙述数据的提取和合成.
主要成果:
- 二十九项研究证实了线粒体功能障碍和子宫前 (PE),IUGR,胎儿生长限制 (FGR) 和早产 (PTB) 之间的一致联系.
- 常见的发现包括减少mtDNA拷贝数,减少ATP生产,增加反应性氧物种 (ROS) 和破坏线粒体动态 (增加DRP1,减少MFN2).
- 早期发病的PE和对称的FGR显示出特别严重的胎盘线粒体异常,表明主要的胎盘起源.
结论:
- 胎盘线粒体功能障碍是导致不良妊娠结果的重要因素.
- 跨疾病一致的分子特征为向治疗和预测生物标志物提供了潜在的潜力.
- 进一步的研究可以通过针对胎盘线粒体的干预措施来改善母胎健康.
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