身体脂肪分布和胰岛素敏感性对体外受精结果的影响:一项前性观察性研究
Andrea Roberto Carosso1, Alberto Revelli2, Alessandro Ruffa1
1Obstetrics and Gynecology 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, Sant'Anna Hospital, University of Torino, 10126 Turin, Italy.
Journal of clinical medicine
|June 13, 2025
概括
腰围和腰与部的比例比BMI更好地表明卵巢对生育治疗的反应. 较高的上体脂肪会对卵巢对淋巴激素的敏感性产生负面影响,尽管活产率不受影响.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
- 肥胖和新陈代谢 肥胖和新陈代谢
背景情况:
- 全球肥胖患病率不断上升,需要了解其对生育治疗的影响.
- 身体质量指数 (BMI) 是对肥胖的有限衡量标准,不考虑身体脂肪的分布.
- 腰围 (WC) 和腰比 (WHR) 可能可以更好地了解生育治疗的结果.
研究的目的:
- 评估WC和WHR作为在体外受精 (IVF) 周期中的卵巢反应的预测指标.
- 为了比较WC和WHR与BMI对卵巢反应的预测值.
- 调查身体脂肪分布与卵巢敏感度指数 (OSI) 之间的关联.
主要方法:
- 对265对夫妇进行前性观察性研究,他们接受了第一次试管婴儿/细胞内质精子注射 (ICSI) 治疗.
- 在招生时评估BMI,WC,WHR,以及对胰岛素敏感性的恒温模型评估 (HOMA).
- 主要结果:人体测量/代谢变量与OSI之间的相关性 ([(获取的卵细胞/总淋巴激素剂量) × 1000]).
主要成果:
- 较高的WC和WHR与较低的OSI显著相关,独立于BMI.
- 与WC ≤80厘米 (p <0.05) 相比,WC>80厘米的妇女的OSI显着较低.
- 与WHR ≤0.85 (p <0.05) 的女性相比,WHR>0.85的女性的OSI显着较低. 活产率在各组之间没有显著差异.
结论:
- 身体脂肪的分布,特别是上体脂肪 (用WC和WHR表示),在受控卵巢刺激期间与卵巢对淋巴激素的敏感性有负相关性.
- 在试管婴儿中,WC和WHR似乎是卵巢反应的更敏感指标,而不是BMI.
- 虽然卵巢敏感性受到影响,但试管婴儿中活产率的临床相关性似乎很小.
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