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Updated: Jun 16, 2025

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
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重复的压缩负荷降低了线粒体的功能,并通过在骨关节性肌肉细胞中协同激活NAD依赖的Sirtuin 1和Runx2来提高了软骨基质降解酶MMP-13的活性

Masahiro Takemoto1, Yodo Sugishita2, Yuki Takahashi-Suzuki2

  • 1Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8512, Japan.

International journal of molecular sciences
|June 13, 2025
PubMed
概括

在骨关节炎 (OA) 中,重复的机械应激会通过降低尼古丁胺胺氨基二核酸 (NAD) 和ATP的产生,导致矩阵降解酶MMP-13的增加,从而导致胆固醇细胞中的线粒体功能障碍.

关键词:
冠状腺细胞 冠状腺细胞矩阵金属蛋白酶 (MMP) -13 - - 基质金属蛋白酶 (MMP) - - 基质金属蛋白酶线粒体活动的线粒体.尼古丁胺胺腺因二核酸 (NAD) 是一种骨关节炎是一种关节炎.经常重复的机械应力.与子相关的转录因子 (Runx) 2 2在Sirtuin 11中使用.

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