相关实验视频

Updated: Jun 16, 2025

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

日本结肠直肠癌精准医学的现状

Yoshiki Kojitani¹, Masayuki Takeda¹

¹Department of Cancer Genomics and Medical Oncology, Nara Medical University, 840 Shijo-Cho, Kashihara 634-8521, Nara, Japan.

International journal of molecular sciences

|June 13, 2025

概括

精准医学优化了在日本使用关键生物标志物和先进诊断的结直肠癌 (CRC) 治疗. 测试时间,治疗可用性和访问方面的挑战仍然存在,需要进一步研究以改善患者的治疗结果.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
药理学药理学是指药理学的学科.

背景情况:

结肠直肠癌 (CRC) 在日本是一个重大的健康挑战.
精准医学对于优化CRC治疗策略至关重要.
生物标志物指导针对性疗法和免疫疗法在CRC管理.

研究的目的:

审查日本结肠直肠癌精准医学的现状.
要突出关键的生物标志物,诊断方法和治疗选择.
讨论CRC精密瘤学的挑战和未来方向.

主要方法:

对日本目前的文献和临床举措进行了全面的审查.
对关键生物标志物的分析 (RAS,BRAF,MSI/MMR,HER2,RET,NTRK的融合).
检查诊断技术,如全面的基因组分析和ctDNA分析.

主要成果:

确定了关键生物标志物和先进的诊断,使精确的治疗选择成为可能.
突出了全国性的举措 (c-CAT,SCRUM-Japan) 和现实世界的数据利用.
通过ctDNA分析 (CIRCULATE-Japan GALAXY研究) 在最小残留疾病监测方面取得了重大进展.

结论:

以生物标志物和先进诊断为指导的精准医学正在改变日本的CRC护理.
挑战包括测试周转时间,治疗可访问性和分子瘤板的差异.
未来的努力应集中在扩大临床试验,加快药物批准和现实世界的数据集成上.

关键词:

日本日本日本日本日本.结肠直肠癌是什么意思人类表皮生长因子受体2 分子向疗法是指分子向疗法.精准医学是一门精准医学.

更多相关视频

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...