在接受Janus激酶抑制剂治疗的RA患者中NK细胞和耗尽的Th细胞表型的变化:对副作用的含义

Juan José Fernández-Cabero1, Carmen Lasa-Teja1,2, David San Segundo1,3

  • 1Immunopathology Group, Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.

概括

简氏激酶抑制剂 (JAKis) 改变了类风湿性关节炎 (RA) 患者的免疫细胞,减少NK Dim细胞和转移T细胞群. 这可能会增加JAKis治疗RA患者感染和恶性瘤的风险.

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