在阿片类药物使用障碍患者和替代治疗患者的为期两个月的运动训练计划中,皮质醇和β-内啡反应
Alexandros E Psarianos1,2, Anastassios Philippou3, Argyro Papadopetraki3
11st Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
International journal of molecular sciences
|June 13, 2025
概括
在接受替代治疗的阿片类药物使用障碍患者中,中等强度的有氧运动显著增加了β-endorphin和降低了皮质醇水平. 这表明运动是一种有前途的辅助疗法,用于管理戒断症状并帮助恢复.
科学领域:
- 神经内分泌学神经内分泌学
- 运动生理学 运动生理学
- 成 药物 药物 药物 药物
背景情况:
- 运动会影响神经激素系统,影响压力和快乐.
- 皮质醇和β-endorphin是药物戒断症状的关键调节剂.
- 阿片类药物使用障碍 (OUD) 治疗通常涉及用甲或布普伦诺芬进行替代疗法.
研究的目的:
- 为了研究一个为期两个月的中等强度有氧运动计划对唾液皮质醇和β-endorphin水平的影响.
- 评估OUD患者在短期戒除甲/布诺芬期间的这些影响.
- 评估运动作为管理退出和支持恢复的辅助策略.
主要方法:
- 90名接受替代治疗的OUD患者被随机分为运动和对照组.
- 运动组 (n=46) 参与了为期8周的监督中等强度有氧运动 (跑步机,20分钟,每周3次).
- 唾液皮质醇和β-endorphin水平在不同的时间点在运动之前和之后被测量.
主要成果:
- 干预后,这两组运动者表现出beta-endorphin水平的显著增加 (p < 0.05).
- 对照组表现出β-内啡水平的下降.
- 干预后,皮质醇水平在炼组显著下降,在对照组增加 (p < 0.05).
结论:
- 中等强度的有氧运动对OUD患者的β-endorphin和皮质醇水平产生了积极的调节.
- 运动可以通过增加内源性阿片类药物和减少压力激素来缓解戒断症状.
- 身体活动显示出作为成恢复的辅助疗法的潜力,改善情绪调节,并可能降低复发风险.
相关概念视频
Hypothalamic-Pituitary Axis
59.8K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.8K
Exercise and Cardiovascular Response
755
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
755
Hormones of the Adrenal Glands
2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K
Analgesia and Pain Management
553
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
553
Opioid Analgesics: Synthetic and Semisynthetic Opioids
253
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
253
Introduction to Stress and Lifestyle
94
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
94


