作为对慢性心力衰竭严重程度的个性化评估的额外读数,SII,SIRI和MHR作为额外读数
Edis Baubonis1, Jolanta Laukaitienė2, Ingrida Grabauskytė3
1Medicine Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50103 Kaunas, Lithuania.
International journal of molecular sciences
|June 13, 2025
概括
在慢性心力衰竭患者中,较高的单细胞与高血脂比率 (MHR) 表明氧化应激和心脏功能恶化. SII和SIRI的实用性需要进一步研究.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 血液学 血液学 血液学
背景情况:
- 慢性心力衰竭 (CHF) 是一种复杂的疾病,具有显著的发病率和死亡率.
- 反映疾病严重程度和潜在的病理生理过程的生物标志物对于患者管理至关重要.
- 中性细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和单细胞与HDL的比率 (MHR) 是新兴的炎症标志物.
研究的目的:
- 研究SII,SIRI和MHR与CHF患者的脂质图,氧化应激和心声学参数之间的关系.
- 确定SII,SIRI和MHR是否可以作为CHF疾病严重程度和进展的指标.
主要方法:
- 分析了220名CHF患者的队列.
- 患者根据SII,SIRI和MHR水平进行了分层.
- 综合评估包括脂质样本,氧化应激标志物和心声回声.
主要成果:
- 在SII和SIRI组之间没有发现脂质图,氧化应激或心声图的显著差异.
- 较高的MHR与较低的HDL,增加的左心室终端-透气直径 (LVEDD),左心室质量 (LVMM),心肌质量指数 (MMI) 和左心室射出分数 (LVEF) 的降低有关.
- MHR与氧化应激标志物 (蛋白质碳,酸) 和心脏重塑指数 (MMI,LVMI) 相相关.
结论:
- 在CHF患者中,MHR可以作为恶化氧化应激和心脏功能障碍恶化的有价值指标.
- 在CHF中SII和SIRI的临床实用性需要进一步验证.
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