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细胞和糖尿病微血管病变:具有高可塑性和再生能力的组织寄居介质细胞干细胞

Zeinab Shirbaghaee^1,2, Christine M Sorenson^2,3, Nader Sheibani^1,2,4

¹Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

International journal of molecular sciences

|June 13, 2025

概括

细胞 (PCs) 对于血管健康至关重要,并像介酶干细胞 (MSCs) 一样起作用. 在糖尿病中,PC功能障碍导致并发症,但它们为再生医学和血管修复疗法提供了潜力.

科学领域:

血管生物学血管生物学
再生医学是一种再生医学.
糖尿病学糖尿病学

背景情况:

周细胞 (PCs) 是周血管细胞,对血管稳定,血管生成和屏障完整性至关重要.
由于糖尿病的高血糖导致的PC功能障碍,显著导致多个器官的微血管并发症.
PCs表现出介质干细胞 (MSC) 的特征,包括再生和免疫调节能力.

研究的目的:

审查皮质细胞作为组织寄存的介质细胞干细胞的新兴作用.
突出表皮细胞在糖尿病并发症中的病理生理参与.
探索皮细胞在再生医学和治疗应用中的潜力.

主要方法:

在健康和疾病中介细胞功能的文献综述.
对介质细胞特征与介质细胞干细胞相关的分析.
综合当前关于基于细胞的疗法和组织工程的研究.

主要成果:

细胞在维护血管完整性方面发挥着至关重要的作用,并与糖尿病微血管病有关.
细胞具有类似干细胞的特性,这表明组织再生的潜力.
功能障碍的皮质细胞有助于与糖尿病有关的血管退化和受损的愈合.

结论:

细胞正在成为糖尿病血管并发症的关键参与者,充当组织居民干细胞.
细胞对治疗干预和血管组织再生策略具有重大前景.
对细胞生物学和治疗的进一步研究可能会导致糖尿病并发症的新疗法.

关键词:

血的障碍物血的障碍物中枢神经系统中枢神经系统糖尿病并发症糖尿病并发症细胞外囊泡中的细胞外囊泡.代谢活动的代谢活动.周围的血管支细胞.

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