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在VEGFRs的分子成像方面的进展:成像和治疗方面的创新

Hanieh Karimi^1,2, Sarah Lee¹, Wenqi Xu^1,2

¹Department of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.

International journal of molecular sciences

|June 13, 2025

概括

血管内皮生长因子受体 (VEGFRs) 对于血管形成和疾病至关重要. 使用放射性药物的VEGFR向成像为可视化和监测由血管新生和淋巴血管新生驱动的疾病提供了强大的工具.

科学领域:

生物医学成像学生物医学成像学
分子成像学分子成像学
放射性药物科学是一种放射性药物科学.

背景情况:

血管内皮生长因子受体 (VEGFRs) 调节血管生成,淋巴血管生成和血管透性.
对VEGFR信号的失调与癌症,心血管疾病和炎症性疾病有关.
VEGFRs与VEGF配体相互作用,激活细胞增殖,迁移和生存的途径.

研究的目的:

审查使用放射性药物对VEGFR向成像的进展.
探索新的标记物,放射性标记技术及其体内成像特征.
讨论VEGFR成像用于疾病监测的临床前和临床应用.

主要方法:

开发和应用放射性标记的,抗体和标记剂 (例如,Cu-bevacizumab,Zr-ramucirumab).
使用正子发射断层扫描 (PET) 和单光子发射计算机断层扫描 (SPECT) 进行体内成像.
在生理和病理条件下研究VEGFR表达和分布.

主要成果:

向放射性药物可实现VEGFR表达和分布的非侵入性可视化.
PET和SPECT成像提供了对血管和淋巴血管活动的实时洞察.
VEGFR成像有助于了解疾病进展和治疗反应.

结论:

针对VEGFR的成像是诊断和监测血管新生和淋巴血管新生驱动疾病的宝贵策略.
在追踪剂和技术方面的持续创新将加强精确诊断和治疗监测.
未来的发展有望改善与VEGFR相关的病理的管理.

关键词:

在VEGFRs中.血管新生是因为血管新生.淋巴血管生成 (Lymphangiogenesis) 是一种导致淋巴血管发生的过程.核医学成像技术核医学成像技术放射性药物制品放射性药物制品有针对性的治疗.

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