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从染色体异常到转录组分析:四十年的双基因毒性研究

Zenaba Khatir^1,2, Alexandra Leitão¹

¹Environmental Science Center, Qatar University, Doha 2713, Qatar.

International journal of molecular sciences

|June 13, 2025

概括

双体是水生生物基因毒性的关键指标,显示了从细胞遗传分析到转录组学的进步. 研究趋势和多端点分析改善了对海洋污染的环境风险评估.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
遗传学遗传学是一个

背景情况:

双动物在基因毒性研究中作为关键的哨兵生物,因为它们的生态意义和对环境污染物的敏感性.
在过去的40多年里,它们的使用量不断扩大,反映出人们对海洋污染及其遗传影响的日益关注.

研究的目的:

批判性地审查过去四十年来双动物中基因毒性研究的演变.
综合方法学的进步,研究趋势和环境风险评估多端点分析的整合.
确定当前的挑战,并提出未来的研究方向,以评估和减轻海洋生态系统的遗传损害.

主要方法:

综合性文献综述综合了四十年来关于双生物遗传毒性的研究.
分析从细胞遗传学试验到转录基因方法的方法进展.
考察地理研究趋势,并纳入多个终点分析.

主要成果:

记录了双动物中基因毒性测试方法的演变,突出了技术进步.
确定了双生物遗传毒性研究的关键地理区域和趋势.
证明了多个终点策略对于可靠的环境风险评估的重要性日益增加.

结论:

双基因毒性研究已经显著发展,为环境监测提供了复杂的工具.
综合方法提高了评估海洋污染物的遗传损害的一致性和可靠性.
未来的研究应该专注于解决持续存在的挑战,以改善污染对遗传影响的评估和减轻.

关键词:

它们是DNA DNA DNA DNA.两子两子化学压力因素化学压力因素细胞遗传学细胞遗传学基因基因基因基因遗传毒性遗传毒性遗传毒性分子反应的分子反应.翻译学翻译学翻译学翻译学

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