复杂性与风险相遇-下一代基因组编辑植物的挑战 欧盟环境风险评估的确立概念
Marion Dolezel1, Marianne Miklau1, Andreas Heissenberger1
1Land Use & Biosafety Unit, Umweltbundesamt-Environment Agency Austria, Spittelauer Laende 5, 1090 Vienna, Austria.
Plants (Basel, Switzerland)
|June 13, 2025
概括
对转基因植物 (GMP) 的环境风险评估 (ERA) 的比较方法对于复杂的修改是不够的. 对于未来的转基因植物风险评估,需要以假设为导向的全植物评估.
科学领域:
- 农业生物技术 农业生物技术
- 环境科学 环境科学
- 风险评估 风险评估
背景情况:
- 转基因植物 (GMP) 传统上经过环境风险评估 (ERA),使用与非转基因品种的比较方法.
- 基因工程的进步使复杂的修改成为可能,导致具有改变特征的新型植物表型,可能缺乏与比较物的等价性.
研究的目的:
- 评估欧盟当前对复杂的GMP应用的比较安全评估方法的有效性.
- 在处理新型植物表型和改变的代谢途径时,确定现有的ERA实践中的弱点.
主要方法:
- 分析涉及具有复杂代谢途径修改的GMP的案例研究.
- 评估欧盟目前对ERA的比较安全评估框架.
主要成果:
- 传统的比较评估方法在复杂的良好生产规范中应用时,会出现显著的局限性.
- 现有的方法很难为新型植物表型和系统代谢变化提供足够的信息.
结论:
- 基于假设的评估,包括整个植物的实验评估和各种保护目标,应该补充当前的ERA实践.
- 生态现实的评估对于未来的ERA变得越来越复杂的植物修饰,包括合成生物学植物至关重要.
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