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生物聚合物/接聚合物相互作用:它是生物假体化的关键吗?

Irina Yu Zhuravleva¹, Anna A Dokuchaeva¹, Andrey A Vaver¹

¹Institute of Experimental Biology and Medicine, E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation (E. Meshalkin NMRC), 15, Rechkunovskaya str., Novosibirsk 630055, Russia.

|June 13, 2025

概括

由聚 (PET),聚烯 (PP) 和聚四乙烯 (PTFE) 制成的可以导致牛心膜 (BP) 植入物中化. 佩特 sutures 显示了最少的化,表明它可能是BP假肢的首选选择.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
医疗器械研究医疗器械研究

背景情况:

牛心膜 (BP) 是用于医疗器械的常见生物聚合物支架.
BP植入物的化仍然是一个重大挑战,影响设备的寿命和性能.
相关的手术材料对BP化的影响尚未完全理解.

研究的目的:

调查聚 (PET),聚烯 (PP) 和聚四乙烯 (PTFE) 接材料对环氧保护牛心脏 (BP) 化的影响.
在与BP植入物一起使用时,比较不同接材料的化潜力.
评估与BP植入物和各种接相关的细胞反应和物质降解.

主要方法:

接和非接的BP样品的皮下植入,以及合成聚合物控制 (REPEREN®),在老鼠身上进行30,60和90天.
使用原子吸收光谱学量化含量的量.
扩展剂的组织学检查 (血素和欧,·科萨染色) 和微结构分析 (SEM,EDS),以评估化和材料相互作用.

主要成果:

在非接的BP或在任何REPEREN®对照组中没有观察到化.
制的BP样本呈现出含量逐渐增加和Ca/P比率,表明90日后的氧酸盐形成.
聚 (PET) 接导致在测试接材料中观察到的含量最低,与其他接相比,细胞反应较少明显.

结论:

所有经过测试的手术接材料 (PET,PP,PTFE) 都可以在牛心周植入物中引起化.
与PP和PTFE相比,聚 (PET) 似乎对BP化产生最小的负面影响.
接材料的选择是缓解化和改善BP医疗器械长期性能的一个关键因素.

关键词:

在REPEREN®中,使用REPEREN®.生物假体心脏门化的化过程原蛋白是一种原蛋白.接材料的接材料.

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