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低卡路里和非常低卡路里饮食以及肥胖住院患者的药物使用:一项横截面研究
Sérgio de Queiroz Braga1, Márcia Cristina Almeida Magalhães Oliveira1,2,3, Matheus Jorgetti Chamorro2
1Hospital da Obesidade, Camaçari 42825-901, Brazil.
Healthcare (Basel, Switzerland)
|June 13, 2025
概括
在六个月内,重度肥胖的住院患者的强化低热量饮食和生活方式改变显著减少了药物需求,特别是高血压. 这突显了住院多学科肥胖管理的有效性.
科学领域:
- 代谢和内分泌学
- 心血管健康 心血管健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是一个全球性健康危机,与多种疾病和大量药物使用有关.
- 二级和三级肥胖症在管理并发病和治疗负担方面存在重大挑战.
- 对严重肥胖的有效住院治疗策略对于改善患者的治疗结果至关重要.
研究的目的:
- 评估低卡路里和非常低卡路里饮食 (LCD/VLCD) 结合强化生活方式改变对伴随性疾病的影响.
- 评估在住院肥胖患者中对高血压,糖尿病和脂质失调的药物使用的变化.
- 确定住院多学科护理对严重肥胖管理的有效性.
主要方法:
- 对246名患有II和III类肥胖症的患者进行了回顾性队列研究,这些患者在医院住院3-6个月.
- 对抗高血压,低血糖和降脂药物处方数据的分析,在入院时,3个月和6个月.
- 药物使用和体重变化的统计比较,使用描述性统计,基平方和t测试.
主要成果:
- 服用抗高血压药物的比例显著下降,从入院时的74.4%降至6个月后的44.7% (p < 0.02).
- 低血糖处方在3个月后显著减少 (p = 0.01),但在6个月后没有显著减少.
- 3个月的平均体重减轻率为11%,6个月的平均体重减轻率为21.3%;没有观察到降脂药物使用的显著变化.
结论:
- 包括LCD/VLCD和生活方式治疗在内的住院治疗导致严重肥胖症的药物负担短期减少.
- 抗高血压药物使用的显著下降表明对心血管并发症有积极影响.
- 住院患者的多学科策略显示出对管理严重肥胖和减少相关药物依赖的承诺.
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