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кворум感知和流动性病原性细菌的抑制由Fulvifomes mexicanus sp. 没有了,没有了

Angelica Bolaños-Nuñez^1,2, Michelle Martínez-Pineda¹, Ricardo Valenzuela¹

¹Departamento de Botánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Mexico City 11340, CDMX, Mexico.

Molecules (Basel, Switzerland)

|June 13, 2025

概括

发现了一种新的真菌,Fulvifomes mexicanus,其提取物显示出抑制细菌毒性因子的潜力. 这一发现为开发针对耐药细菌的新抗菌剂提供了一个新的来源.

科学领域:

菌类学菌类学是指菌类学.
微生物学微生物学
自然产品化学自然产品化学

背景情况:

抗微生物耐药性需要发现针对细菌毒性的新型化合物.
,特别是来自Basidiomycota类的真菌,是生物活性分子的公认来源.

研究的目的:

为了描述一种新的真菌物种,Fulvifomes mexicanus.
为了研究F. mexicanus提取物的抗病原潜力.
为了描述F. mexicanus代谢物的化学组成.

主要方法:

用于物种识别的形态和遗传学分析.
生物测试以评估抑制Pseudomonas aeruginosa运动性和Chromobacterium violaceum violacein生产的生物测试.
使用液体染色学-高分辨率电喷射电离化质谱学 (LC-HRESIMS) 和分子网络的代谢分析.

主要成果:

一个新的物种,Fulvifomes mexicanus,被正式描述.
墨西哥的甲醇提取物抑制了细菌的运动性和紫色素的产生.
通过LC-HRESIMS和分子网络识别了各种代谢物,包括希斯皮丁衍生物,类和类.

结论:

墨西哥富尔维福姆斯 (Fulvifomes mexicanus) 是一种抗病原化合物的新来源.
已识别的代谢物有助于观察到的生物活性.
这项研究支持从F. mexicanus.中提取的新抗菌剂的开发.

关键词:

富尔维福姆斯墨西哥人 sp. 在新的一年里.它具有抗病原性活性.代谢分析代谢分析

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