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Updated: Jun 14, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
在六种纯溶剂和两种二进制溶剂中,红二酸二的热力学行为
Jin Feng1, Xunhui Li1, Lianjie Zhai2
1National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
这项研究确定了红红三酸二酸盐在各种溶剂中的溶解度. 溶解度受温度和溶剂类型的影响,而酒精溶剂的溶解度更高.
科学领域:
- 制药科学 制药科学
- 物理化学 物理化学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 热力学参数对于优化结晶过程至关重要.
- 了解溶解度是药物配方和制造的关键.
研究的目的:
- 在各种溶剂中确定 erythromycin thiocyanate dihydrate 的溶解性概况.
- 评估影响结晶的热力学参数.
- 使用数学模型对实验溶解度数据进行相关联.
主要方法:
- 在大气压下 (0.1 MPa) 测定可溶性.
- 在六个单溶剂系统 (酒精,,水) 和两个二元溶剂混合物 (水-酒精) 中进行调查.
- 温度范围: 278.15 318.15 K. 温度范围: 278.15 318.15 K.
- 使用Apelblat,Yaws,Van't Hoff,Apelblat Jouyban Acre和CNIBS/R-K模型的可溶性数据的相关性.
主要成果:
- 红红二酸盐二酸盐的溶解度受到温度和溶剂成分的显著影响.
- 与溶剂和水相比,在酒精溶剂中观察到更高的溶解度.
- 随着二元溶剂混合物的水含量增加,溶解度会降低.
- 阿佩尔布拉特模型证明了它最适合单溶剂系统.
- 阿佩布拉特和CNIBS/R-K模型为二元溶剂系统提供了更好的相关性.
结论:
- 溶剂的选择和组成对于控制红红二酸二酸盐结晶至关重要.
- 数学模型,特别是阿佩尔布拉特模型,对于预测溶解度是有效的.
- 这些数据有助于优化红红二酸二酸盐的结晶过程.
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