大型黄色鱼蛋白分离物/格兰水凝改善了黄素对DSS诱导的大肠炎的缓解作用
Yi-Nan Du1, Yi-Xu Wang1, Jia-Nan Yan1
1SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Key Laboratory of Aquatic Product Processing and Quality Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Foods (Basel, Switzerland)
|June 13, 2025
概括
大型黄色croaker蛋白质分离物/凝糖水凝有效地提供黄素,通过恢复肠道微生物群和减少炎症,显著缓解小鼠的性结肠炎症状.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 黄素 (Cur) 具有抗炎性质,但由于口服供应的生物利用性较差.
- 开发有效的黄素输送系统对于管理UC至关重要.
研究的目的:
- 开发和评估蛋白质分离物/凝 (PG) 二元水凝作为黄素 (Cur) 的输送系统.
- 在硫酸 (DSS) 诱导的性结肠炎 (UC) 鼠标模型中研究PG-Cur的治疗疗效.
主要方法:
- 制造PG二元水凝,用于嵌入和输送黄素.
- 在小鼠中使用DSS诱导UC.
- 使用PG-Cur和评估大肠炎症状,包括减肥,腹和结肠长度.
- 测量炎症标志物 (IL-1β,IL-6,TNF-α,IL-10) 和酶活动 (MPO,iNOS).
- 便微生物群分析以评估肠道失调.
主要成果:
- 在DSS诱导的大肠炎小鼠中,PG-Cur治疗显著缓解了体重减轻,腹和结肠缩短.
- 与自由黄素相比,PG-Cur的使用导致炎症标志物和酶活性显著改善.
- 便微生物群分析表明,PG-Cur通过丰富有益细菌和减少有害细菌来恢复肠道失调.
结论:
- 大型黄色croaker蛋白质分离物/凝糖水凝作为口服黄素输送的有效载体.
- 在小鼠中,PG-Cur在缓解DSS诱导的性结肠炎方面表现出显著的治疗潜力.
- 这种新的水凝系统有望为UC管理开发改进的口服黄素配方.
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