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Updated: Jun 14, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

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核酸模拟抑制剂的结构基础和合理设计 逃避SARS-CoV-2校对酶

Junbo Wang1, Yufan Pan2, Yixiao Liu1

  • 1MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing 100084, China.

Journal of the American Chemical Society
|June 13, 2025
PubMed
概括

核酸类似物 (NA) 可以逃避SARS-CoV-2 nsp14外核酶 (ExoN) 的分裂. 对NA的基和核糖部分的修改是逃避nsp14 ExoN活性的关键,为抗病毒药物设计提供了信息.

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