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Updated: Jun 14, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
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合成新的N,N ́-腹尿素及其作为大麻素-1受体抑制剂的理论研究

Eirini Tsemperlidou1, Nikitas Georgiou2, Demeter Tzeli2

  • 1University of Ioannina - Ioannina Campus: Panepistemio Ioanninon - Panepistemioupole Ioanninon, Department of Chemistry, GREECE.

ChemPlusChem
|June 13, 2025
PubMed
概括

研究人员开发了新的N,N-尿素,作为潜在的大麻素-1 (CB-1) 受体抑制剂. 计算研究表明对CB-1受体具有强烈的结合亲和力,其中一种化合物表现优于已知的抑制剂.

关键词:
基于Pyrazolo的腹尿素 * 基于Triazolo的腹尿素 * 卡纳比诺伊德-1受体 * DFT * 分子对接 * 分子动力学

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