整合素Alpha8β1 (81):对一个被忽视的RGD结合受体进行了深入的审查
Iman Ezzat1, Marisa Zallocchi1
1Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
概括
整合素α8β1 (α8β1) 对于器官发育至关重要,特别是在脏和内耳. 这种受体在组织修复,癌症和听力功能中发挥作用,具有潜在的治疗应用.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 分子医学是分子医学.
背景情况:
- 集成蛋白是介导细胞-细胞外基质相互作用的跨膜受体,对组织发育和功能至关重要.
- 整合素家族包括24种异构组合,其中只有8种识别了阿尔金氨酸-甘氨酸-酸盐 (RGD) 基因.
- 整合素α8β1 (α8β1) 是一种关键的RGD结合整合素,特别是在收缩细胞中,由Ras同源基因家族成员A (RHOA) 调节.
研究的目的:
- 审查最近的进展,了解整合素α8β1 (α8β1) 在器官发育过程中的功能.
- 探索α8β1在和内耳发育中的作用.
- 讨论α8β1在损伤,疾病,癌症中介细胞转移到上皮细胞的参与以及听觉功能.
主要方法:
- 本综述综合了最近关于α8β1功能的研究结果.
- 文献搜索侧重于与有机生成,疾病病理学和癌症发展相关的研究,涉及α8β1.1.
- 对α8β1信号传输的分子机制和功能后果的分析.
主要成果:
- α8β1是和内耳发育中的关键调节器.
- 该受体参与受伤后的组织修复过程.
- 在癌症进展过程中,α8β1在介质细胞向上皮细胞的过渡中发挥着重要作用,对听觉功能至关重要.
结论:
- 整蛋白α8β1是多种发育过程中的关键调节剂,包括和内耳形成.
- α8β1的失调与疾病状态有关,包括癌症和听力障碍.
- α8β1作为各种疾病的诊断和治疗点具有前途.
相关概念视频
01:10Integrins
3.9K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
3.9K
01:17Intracellular Signaling Affects Focal Adhesions
2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.6K
01:15Activation of Integrins
3.4K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
3.4K
01:30Transducer Mechanism: G Protein–Coupled Receptors
1.9K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
GPCRs are also called heptahelical,...
1.9K
01:15G Protein-coupled Receptors
11.6K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
11.6K
01:21G-protein Coupled Receptors
117.3K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
117.3K