带道综合征归因于药物使用:一项药监测研究
Andrew Mihalache1, Emily Volfson1, Ryan Huang1
1Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, CAN.
Cureus
|June 13, 2025
概括
这项研究确定了在FDA不良事件报告系统 (FAERS) 中不成比例地与手腕道综合征 (CTS) 相关的十种药物. 对于那些被处方这些药物的患者来说,提高警至关重要.
科学领域:
- 药监和药物安全 药监和药物安全
- 神经学和神经科学 神经学和神经科学
- 临床药理学 临床药理学
背景情况:
- 管综合征 (CTS) 是一种常见的神经压缩障碍,具有已知的机械和系统风险因素.
- 药理学剂对CTS发展的潜在贡献在历史上被研究不足.
- 识别与药物相关的风险对于患者安全和临床决策至关重要.
研究的目的:
- 为了确定不成比例地与手腕道综合征 (CTS) 相关的特定药物.
- 分析食品和药物管理局关于药物-CTS关联的不良事件报告系统 (FAERS) 的数据.
- 告知临床医生关于与CTS相关的潜在药理学风险.
主要方法:
- 对FAERS数据 (2003年10月至2024年9月) 对于手腕道综合征 (CTS) 的不良事件的回顾性药监分析.
- 纳入标准:在至少10份CTS不良事件报告中,药物被列为首要嫌疑人.
- 使用报告赔率比率 (ROR) 和贝叶斯信心传播神经网络算法进行信号验证的不成比例分析.
主要成果:
- 在12929504例报告的不良事件中,6837例 (0.05%) 涉及手掌道综合征 (CTS).
- 十种药物显示出CTS的显著过度报告,包括idursulfase,galsulfase,laronidase,tesamorelin,anastrozole,alendronic acid,gamma-hydroxybutyric acid (GHB),rofecoxib,alendronate和tafamidis. 这些药物中,有10种药物显示出CTS的显著过度报告,包括idursulfase,galsulfase,laronidase,tesamorelin,anastrozole,alendronic acid,gamma-hydroxybutyric acid (GHB),rofecoxib,alendronate和tafamidis.
- 对于几个药物类别,观察到高报告几率 (ROR),表明与CTS有很强的关联.
结论:
- 几个药物类别,包括酶替代疗法 (ERT),芳香酶抑制剂,双酸盐和其他药物,不成比例地与手腕道综合征 (CTS) 相关.
- 建议在这些已识别的药物被处方给患者时提高意识和监测新的或恶化的CTS.
- 临床医生在评估手腕道综合征时,应彻底审查患者的药理史.
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