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不同剂量的葡萄糖皮质激素对突然耳聋的有效性和副作用

Ya He¹, Liang'e Zhi², Yajin Feng¹

¹Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of the Army Medical University, Chongqing, China.

Current therapeutic research, clinical and experimental

|June 13, 2025

概括

高剂量的皮质类固醇治疗突然失聪没有显著的疗效差异,但糖尿病患者的葡萄糖风险增加. 适当的剂量 (10 mg/d) 可能是糖尿病患者突然聋的最佳剂量.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

突发性耳聋 (SD) 是一种快速的感觉神经听力损失,原因不明.
系统性皮质类固醇是SD的第一线治疗方法,但高剂量可能会导致高血压和高血糖.
最佳的SD治疗方案仍在讨论中.

研究的目的:

为了比较不同剂量的葡萄糖皮质激素在突然聋患者的疗效和副作用.
为了确定最佳的德克萨米他剂量,用于治疗突然的聋.

主要方法:

248名突然聋患者被分为三组,接受初始剂量为10毫克/天,15毫克/天或20毫克/天的德克萨梅他.
治疗的有效性是通过平均听力值升高来评估的.
在糖尿病或高血压患者中,通过血糖和血压监测副作用.

主要成果:

不同的德克萨米他剂量组之间没有发现治疗疗效的显著差异 (P > 0.05).
较高的德克萨米他剂量显著增加了糖尿病患者快速血糖升高的风险.
两组之间没有观察到血压波动的显著差异.

结论:

十毫克/天,十五毫克/天和二十毫克/天的德克萨米他剂量在治疗突然聋方面表现出相似的疗效.
高剂量的德克萨米他会增加糖尿病患者高血糖的风险.
对于患有糖尿病的突然聋患者,建议使用足够的葡萄糖皮质激素剂量 (10毫克/天).

关键词:

管理剂量管理剂量这是一种皮质类固醇.突然的耳聋是什么意思

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