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摄入部分水解的瓜尔可以通过对小鼠的益生菌作用抑制亚托皮炎类症状

So Morishima^1,2, Aya Abe², Saki Okamoto²

¹Laboratory of Food Function, Department of Life Sciences, Graduate School of Bioresources, Mie University, 1577 Kurimamachiya, Tsu, Mie 514-8507, Japan.

Journal of clinical biochemistry and nutrition

|June 13, 2025

概括

部分化瓜尔 (PHGG) 消费通过增强肠道细菌,减少了小鼠的亚托皮炎 (AD) 症状. 这表明PHGG可以通过调节肠-免疫-皮肤轴来有益于皮肤健康.

科学领域:

微生物组研究的研究.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

人们越来越认识到肠道微生物群与皮肤健康的联系.
肠道微生物组是一个潜在的治疗皮炎 (AD) 的潜在治疗点.
亚托匹性皮肤炎是一种具有复杂病因的慢性炎症性皮肤疾病.

研究的目的:

为了研究部分化瓜尔 (PHGG) 减轻AD类症状的疗效.
探索涉及肠道微生物组调节和免疫反应的潜在机制.
在小鼠模型中评估PHGG对肠-免疫-皮肤轴的影响.

主要方法:

在BALB/c小鼠中诱导AD类症状,使用局部的1-Chloro-2,4-dinitrobenzene (DNCB).
在四周的饮食中使用PHGG.
评估表皮屏障完整性,表皮质增生,肠道微生物组合和血清细胞因子水平 (IL-4,IL-10).

主要成果:

养PHGG显著降低了AD类症状,包括表皮屏障破坏和增生症 (p<0.05).
PHGG调节了肠道微生物群,导致酸盐产量增加 (p<0.05).
在PHGG养小鼠 (p<0.05) 中观察到Th2细胞因子 (IL-4和IL-10) 的水平降低,表明Th2免疫反应被抑制.

结论:

摄入PHGG可以改善小鼠的AD症状,可能是通过肠道微生物组调节.
肠道微生物组增强的酸盐生产在抑制Th2免疫反应方面发挥着作用.
这些发现支持肠-免疫-皮肤轴作为阿尔茨海默病的治疗点,PHGG显示了潜在的益处.

关键词:

亚托邦性皮肤炎的发生.黄油酸盐黄油酸盐是一种我们的肠道微生物组.免疫调节免疫调节免疫调节部分化 guar 乳糖部分化

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