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相关概念视频

Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Chemical reactions often occur in a stepwise fashion involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs. Each of the steps in a reaction mechanism is called an elementary reaction. These...
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Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions. 
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Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
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Equilibrium calculations for systems involving multiple equilibria are often complex. For example, to calculate the solubility of a sparingly soluble salt in an aqueous solution in the presence of a common ion, one must consider all the equilibria in this solution. Calculations for these systems can be complicated and tedious, so a systematic approach with a series of steps is often helpful. The process is detailed below.
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从反应物到产品:生物合成路径设计的计算方法.

Shaozhen Ding1, Dongliang Liu1, Yu Tian1

  • 1Department of Chemical and Biomolecular Engineering, School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China.

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概括

为合成生物学设计生物合成途径是复杂的. 本综述涵盖了路径设计的计算工具,包括生物数据,逆合成和酶工程,以提高效率和准确性.

关键词:
生物大数据是生物大数据.酶工程是什么?酶工程是什么?复合成分析的方法.

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科学领域:

  • 合成生物学 合成生物学
  • 代谢工程是代谢工程.
  • 生物技术是生物技术.

背景情况:

  • 合成生物学旨在通过酶途径产生有价值的化合物.
  • 生物合成途径的手工设计具有挑战性和耗时.
  • 计算方法已经显著提升了路径设计.

研究的目的:

  • 审查生物合成路径设计的关键计算工具.
  • 要突出生物数据,逆合成和酶工程的整合.
  • 提高合成生物学中路径设计的效率和准确性.

主要方法:

  • 对生物大数据资源 (化合物,反应,酶) 的审查.
  • 分析用于途径预测的逆合成方法.
  • 讨论使用数据挖掘的酶工程技术.

主要成果:

  • 确定用于路径设计的关键计算工具.
  • 展示多维数据如何帮助路径预测.
  • 强调数据挖掘在酶发现和设计中的作用.

结论:

  • 整合生物大数据,逆合成和酶工程改善了途径设计.
  • 计算工具对于高效准确的生物合成路径构建至关重要.
  • 这些领域的进展加速了合成生物学中增值化合物的生产.