肠道菌群的进步用于CRC的发展,诊断和治疗
Ruiyao Hu1, Yuting Qiu1, Dong-Ang Liu1
1Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Frontiers in microbiology
|June 13, 2025
概括
肠道微生物群影响结肠直肠癌 (CRC) 的发展,诊断和治疗. 了解肠道菌群为个性化CRC预防和治疗提供了新的途径.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 大肠直肠癌 (CRC) 是癌症死亡的主要原因.
- 肠道微生物群在CRC病变发生过程中发挥着关键作用,影响其发病和进展.
- 特定的肠道细菌与CRC的发展有关,并可能影响治疗结果.
研究的目的:
- 审查肠道菌群和结直肠癌之间的复杂关系.
- 探索肠道微生物群在CRC发展,诊断和治疗策略中的作用.
- 突出基于微生物群的干预措施对个性化CRC管理的潜力.
主要方法:
- 关于肠道微生物组和CRC的研究的文献综述.
- 对与CRC风险和进展相关的细菌物种的分析.
- 评估益生菌在CRC治疗和预防中的作用.
主要成果:
- 某些细菌,如Fusobacterium nucleatum和Enterotoxigenic Bacteroides fragilis,与CRC风险增加有关.
- 肠道微生物群代谢物,免疫调节和屏障功能是CRC的关键机制.
- 益生菌,如Bifidobacteria,显示出提高化疗/免疫疗法的疗效和减少副作用的潜力.
结论:
- 肠道菌群是CRC病因学的组成部分,作为潜在的诊断生物标志物.
- 准肠道微生物组为CRC预防和辅助治疗提供了有希望的策略.
- 通过了解宿主微生物群相互作用,可以推进个性化CRC预防和治疗.
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