在患有后COVID-19综合征的患者中,尿路细菌代谢物的度
Natascha Brigo1, Wolfram Mayr1, Maja Taenzer1
1Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Frontiers in cellular and infection microbiology
|June 13, 2025
概括
这项试点研究在COVID-19后综合征 (PCS) 患者中发现了改变的细菌尿素代谢物 (BUM),这表明肠道失调可能导致持续症状. 特定的BUM模式是那些患有后传染性综合征的人独特的.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 免疫学 免疫学 免疫学
背景情况:
- 后COVID-19综合征 (PCS) 涉及COVID-19后持续的症状,其机制尚不清楚.
- 肠道微生物群失调和氨基酸代谢的改变是潜在的贡献者.
- 细菌尿性代谢物 (BUM) 可能在后感染性综合征中起作用.
研究的目的:
- 在患有后传染性综合征的患者中调查BUM的变化.
- 为了确定BUM变化是否与PCS症状有关.
- 探索尿液代谢学在了解PCS中的实用性.
主要方法:
- 试点研究涉及25名PCS患者,8名ME/CFS患者和8名健康对照.
- 用质谱法测量尿液中的BUM度.
- 标准化问卷评估了身体,认知,心理和身体症状.
主要成果:
- PCS和ME/CFS患者报告了更高的运动后不适和体质症状严重程度.
- 在64%的PCS患者中发现了升高的BUM,而在对照组和ME/CFS患者中为37.5%.
- 观察到明显的代谢模式,在后传染性综合征患者中增加了三胺,HPHPA,希普酸和三甲基胺.
结论:
- 尿液代谢分析显示了在PCS中识别肠道失生症标志物的潜力.
- 特定的BUM变化可能与后感染性综合征的病理生理学有关.
- 需要进一步的研究来证实BUM在PCS和ME/CFS中的作用.
相关概念视频
Urine Studies I: Urinalysis
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urine Studies II: Urine Culture and Sensitivity Test
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Urinary Tract Infection II: Pathophysiology
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...


