在疲劳状态下健康个体的唾液微生物组的表征
Xianhui Peng1, Na Han1, Yanan Gong1
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Frontiers in cellular and infection microbiology
|June 13, 2025
概括
生理疲劳会改变唾液微生物群,减少多样性并丰富病原体. 这些变化可以作为疲劳状态的生物标志物,可能通过口腔-微生物组-大脑轴.
科学领域:
- 微生物组研究 微生物组研究
- 人体生理学 人体生理学
- 生物标志物发现发现
背景情况:
- 在生理疲劳中对唾液微生物组的理解有限.
- 研究健康个体经历疲劳的变化.
研究的目的:
- 描述疲劳期间唾液微生物组的结构和功能变化.
- 探索唾液微生物组作为潜在的疲劳生物标志物.
主要方法:
- 来自疲劳和对照组的唾液的16S rRNA基因测序.
- 生物信息分析:多样性,差异性分类 (LEfSe),并发网络,生物标志物查 (Boruta-SHAP).
- 微生物社区的表型 (BugBase) 和功能 (PICRUSt2) 预测.
主要成果:
- 疲劳组显示α多样性下降和明显的β多样性.
- 丰富了牙周病原体 (例如,链球菌) 和消耗了与健康相关的属 (例如,Rothia).
- 一个15个基因的模型实现了0.948AUC的疲劳歧视;观察到改变的细菌表型和代谢途径 (神经活性,能量代谢).
结论:
- 生理疲劳显著改变了唾液微生物组的结构和功能.
- 干扰包括减少多样性,病原体丰富和代谢途径转移.
- 唾液微生物组可能通过"口腔微生物组-大脑轴"参与疲劳调节,并显示出作为疲劳生物标志物的潜力.
相关概念视频
What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
Salivary Glands and Saliva
516
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
516
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Muscle Recovery and Fatigue
2.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.0K


