多发性硬化症患者感染,复发和伪复发
Amber Salter1,2, Samantha Lancia1, Mudita Sharma1
1Department of Neurology, Section on Statistical Planning and Analysis, University of Texas Southwestern, Dallas.
Neurology. Clinical practice
|June 13, 2025
概括
多发性硬化症 (MS) 患者的感染增加了复发风险,非COVID感染增加了39%. 然而,COVID-19的感染表明复发的可能性有所降低. 所有感染都显著增加了伪复发风险.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 已知感染会增加多发性硬化症 (MS) 复发和伪复发风险.
- 与其他感染相比,SARS-CoV-2 (COVID-19) 感染对MS复发的具体影响尚不清楚.
- 了解这些关联对于管理MS患者至关重要,因为MS患者更容易感染感染.
研究的目的:
- 为了比较COVID-19感染后复发和伪复发的发生率与MS患者的其他感染.
- 分析MS中不同类型的最近感染和随后的神经事件之间的关系.
主要方法:
- 在2023年春天,北美多发性硬化症登记研究委员会对参与者进行了一项调查.
- 参与者根据最近的感染 (COVID-19,非COVID,两者或没有) 在前6个月内进行分类.
- 统计分析比较了各感染组的复发率和伪复发率,并对共变量进行了调整.
主要成果:
- 非COVID感染增加了39%的复发可能性 (或1.39),而COVID-19感染减少了它 (或0.45).
- 与未感染个体相比,所有感染组的伪复发几率显著增加 (ORs从1.78到3.04).
- 在2,927名参与者中,10%最近患有COVID-19,29.1%患有非COVID感染,8.4%患有两者,52.4%没有感染.
结论:
- 感染,无论类型如何,都与MS患者伪复发的风险更高有关.
- 虽然非COVID感染会增加复发风险,但COVID-19可能会降低复发风险,因此需要进一步调查.
- 多发性硬化症的临床管理应考虑任何感染后急性恶化的风险增加.
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