开发含有泰国草药提取物微乳液,用于治疗疹
Natta Choedchutirakul1, Intouch Sakpakdeejaroen1, Sumalee Panthong1
1Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Journal of advanced pharmaceutical technology & research
|June 13, 2025
概括
这项研究开发了一种优化的微乳液 (ME),用于草药过敏疗法,改善皮肤透和持续释放治疗活性化合物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 疹症状可以使用草药来缓解,但皮肤透率较低限制了疗效.
- 微乳液 (ME) 增强局部药物输送和皮肤吸收.
- 一种特定的草药,Kae-Lom-Pid,显示出对过敏治疗的潜力.
研究的目的:
- 开发和优化含有强效草本提取物的微乳液 (ME),以改善局部输送.
- 评估优化的ME配方的物理化学特性和稳定性.
- 为了评估活性化合物瑞纳丁-C的体外释放特征,
主要方法:
- 使用伪三次相图和混合物设计的配方开发.
- 物理化学表征包括pH值,粒子大小,多分散度指数和泽塔电位.
- 在各种温度周期下进行稳定性测试.
- 在体外药物释放研究里纳坎丁-C.
主要成果:
- 最佳的ME配方包括4%-5%的异甲基,35%-45%的Smix和46%-58%的水.
- 在热循环后,ME表现出稳定的物理性质,低粘度和一致的物理化学参数.
- 观察到持续释放的里纳坎丁-C,在8小时后达到20.21%±0.11%.
结论:
- 开发的微乳液有效地增强了草药过敏疗法的传递.
- 优化的ME配方表现出良好的稳定性和持续的药物释放特性.
- 这种微乳液是开发用于治疗疹的局部草药产品的有希望的模型.
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