克莱因费尔特综合征和ADHD:一个简短的系统审查
Lorenzo Zamboni1, Francesca Fusina2,3, Rebecca Casari1
1Department of Internal Medicine, Unit of Addiction Medicine, G.B. Rossi Hospital, Verona, Italy.
Frontiers in psychiatry
|June 13, 2025
概括
克莱因菲尔特综合征 (KS) 与注意力缺陷多动障碍 (ADHD) 有关,特别是注意力不集中类型. 研究表明,KS个体的ADHD患病率较高,但需要更多的研究来证实因果关系.
科学领域:
- 遗传学和内分泌学
- 神经发育障碍 神经发育障碍
- 精神病学是一个精神病学.
背景情况:
- 克莱因菲尔特综合征 (KS) 是一种性染色体异常 (47,XXY),每500-1000名男性出生的就有1例发生.
- 凯瑟琳综合征与神经发育状况有关,特别是注意力缺陷多动性障碍 (ADHD).
研究的目的:
- 系统地审查和分析关于Klinefelter综合征和ADHD并发症现有的文献.
- 评估KS患者ADHD的患病率,特征和潜在的潜在机制.
主要方法:
- 根据PRISMA指南 (1959-2024) 在Medline和Web of Science进行了全面的文献搜索.
- 在查和应用纳入/排除标准后,选择了15项研究进行分析.
主要成果:
- 观察到KS和ADHD之间存在显著的关联,特别是注意力不集中的亚型.
- 在KS个体中,ADHD的患病率在25%至63%之间,伴随着共患自闭症谱系障碍和情绪障碍的风险更高.
- 神经成像显示了与执行功能和注意力调节相关的KS患者的大脑结构和功能差异.
结论:
- 虽然存在强烈的关联,但缺乏关于KS和ADHD之间因果关系的确证据.
- 在KS患者中,药理性ADHD治疗似乎有效且耐受良好.
- 进一步的研究对于阐明因果机制和开发针对KS-ADHD并发症的量身定制的临床干预措施至关重要.
更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.6K
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
10.3K
相关概念视频
Attention-Deficit/Hyperactivity Disorder
162
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
162
Conduct Disorder
101
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
101
Human Genetics
687
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
687
Karyotyping
62.2K
Overview
62.2K
Sex-linked Disorders
102.7K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.7K
Modeling in Therapy
139
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
139
