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过敏性鼻炎和刺激性肠综合征之间是否存在双向关系? 一个元分析

Yifen Huang¹, Lun Cai¹, Jie Liu¹

¹Department of Internal Medicine, The First Afﬁliated Hospital of Guangxi University of Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China.

Journal of global health

|June 13, 2025

概括

这次元分析发现过敏性鼻炎 (AR) 和易怒肠综合征 (IBS) 之间存在显著的双向联系. 患有AR的患者患上IBS的风险更高,患有IBS的人更有可能患上AR.

科学领域:

胃肠道学和免疫学
过敏研究研究过敏

背景情况:

过敏性鼻炎 (AR) 和易怒肠综合征 (IBS) 之间的潜在关联已被建议,但缺乏足够的证据.
本研究解决了对AR-IBS关系进行全面分析的需要.

研究的目的:

进行元分析,探索过敏性鼻炎和易怒肠综合征之间的双向关系.
量化AR患者患上IBS的风险,反之亦然.

主要方法:

在六个电子数据库中进行了系统的文献搜索.
包括九项相关研究,其中七项专注于AR,两项专注于IBS.
用随机效应的元分析来计算关联的几率比率 (OR).

主要成果:

对10627名AR患者的分析显示,具有统计学意义的IBS发展风险增加 (OR=2.88,P<0.00001).
对1,099名IBS患者的分析显示,在统计学上显著增加了发展AR的风险 (OR=2.15,P<0.00001).
在两种分析中都观察到较低的异质性 (I2=41%和I2=0%).

结论:

过敏性鼻炎和易怒肠综合征之间存在显著的双向关联.
这些发现支持进一步调查连接AR和IBS的潜在机制.

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