身体活动与膝关节骨关节炎之间的关联:全面的系统审查和元分析
Xiaofeng Cui1, Fangfang Xie2, Jiahe Cui2
1The Fourth Clinical Medical College, Xinjiang Medical University, Urumqi, China.
Journal of global health
|June 13, 2025
概括
高度的体力活动 (PA) 增加了膝关节骨关节炎 (KOA) 的风险,而中度的PA没有保护作用. 这一系统性审查阐明了运动和KOA发展之间的复杂关系.
科学领域:
- 整形外科 整形外科 整形外科
- 运动医学 运动医学
- 流行病学 流行病学
背景情况:
- 膝关节关节炎 (KOA) 是一种慢性退行性关节疾病,影响功能和生活质量.
- 身体活动 (PA) 在KOA发展中的作用是有争议的,潜在的保护作用尚不清楚.
研究的目的:
- 系统地审查和元分析PA水平与事件KOA风险之间的关联.
- 为了澄清围绕PA在KOA发展中的作用的临床不确定性.
主要方法:
- 系统地搜索主要数据库 (PubMed,EMBASE,Cochrane,CINAHL,Web of Science) 进行观测研究.
- 在研究选择和质量评估 (纽卡斯尔-太华尺度) 时遵循PRISMA指南.
- 14项符合条件的研究的元分析,涉及超过50万名参与者.
主要成果:
- 与中度的PA相比,高的PA与26%的KOA风险增加有关.
- 与低PA相比,高PA和中等PA都没有显示出对KOA的保护作用.
- 分层分析显示,根据研究设计和地区,存在不同的关联,没有显著的性别差异.
结论:
- 在PA强度和KOA风险之间存在剂量依赖的关系,高强度会增加风险.
- 超过国际PA指南可能会增加KOA风险.
- 需要进一步的研究来确定最佳的PA类型,剂量和持续时间来预防KOA.
相关概念视频
Knee Joint
1.6K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
1.6K
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Bones of the Lower Limb: Femur and Patella
2.3K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
2.3K


