血清尿酸与相对肌肉损失的关联:美国基于人口的横截面研究
Fuquan Wang1,2,3, Lin Wen4,5, Xiaopeng Guo1,2,3
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of cachexia, sarcopenia and muscle
|June 13, 2025
概括
血清尿酸 (SUA) 水平升高与美国成年人相对肌肉损失的风险增加有关. 监测SUA可能有助于早期发现和预防sarcopenia.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 血清尿酸 (SUA) 和肉症之间的关系尚未得到充分证实.
- 相对肌肉损失,定义为附录瘦肉量调整为BMI,是萨尔科佩尼亚的一个关键指标.
- 这项研究调查了美国大量人口中SUA水平与相对肌肉损失之间的关联.
研究的目的:
- 为了检查血清尿酸 (SUA) 水平与相对肌肉损失之间的关联.
- 为了确定是否升高的SUA是萨尔科佩尼亚的独立风险因素.
- 为了探索SUA和肌肉质量之间的剂量反应关系.
主要方法:
- 利用了2011-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 使用FNIH标准 (ALM/BMI) 定义的相对肌肉损失.
- 采用多变量逻辑回归和受限立方线回归,考虑样本重量.
主要成果:
- 包括8967名参与者;7.1%的人有相对肌肉损失.
- 与最低的相比,最高的SUA五分位数显示相对肌肉损失的风险增加了1.78倍 (OR 1.78;95% CI:1.24,2.56).
- 总体上观察到非线性关联,男性和BMI<25 kg/m2或超过体力活动建议的个体的风险线性增加.
结论:
- 血清尿酸 (SUA) 水平升高是美国成年人相对肌肉损失的重要,潜在的独立风险因素.
- 较高的SUA与更高的患病率和肉类的风险有关.
- 对SUA的临床查可能有助于早期识别和预防肌肉损失.
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