身体活动与表观遗传衰老的减少有关:健康与退休研究的发现
Farah Ammous1, Mark D Peterson2, Colter Mitchell1,3
1Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Journal of cachexia, sarcopenia and muscle
|June 13, 2025
概括
定期体育活动与缓慢表观遗传衰老有关,这是生物年龄的标志物. 累积和最近的运动都是关键预测因素,表明运动可以促进更健康的衰老.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 基于DNA甲基化的表观遗传衰老时钟,表明生物年龄,并与健康结果和疾病风险有关.
- 身体活动和炼可能会影响表观遗传衰老,可能促进更健康的衰老和减少慢性疾病.
- 这项研究调查了健康与退休研究中自我报告的体育活动与表观遗传衰老加速 (EAA) 之间的联系.
研究的目的:
- 评估中度至剧烈体力活动与表观遗传衰老加速 (EAA) 之间的关联.
- 检查身体活动的时间和累积如何影响EAA在12年期间.
- 确定身体活动作为促进更健康的生物衰老的干预措施的潜在目标.
主要方法:
- 从白细胞样本中测量了DNA甲基化,并使用第二代表观遗传钟 (GrimAge,PhenoAge,DunedinPACE) 来评估EAA.
- 身体活动是自我报告,并根据频率和强度将其归类为"身体活动".
- 权重线性回归和结构化生命周期建模方法 (SLCMA) 用于横截面和纵向分析.
主要成果:
- 与不活跃的个人相比,身体活跃的参与者在横截面分析中表现出较低的EAA.
- 使用SLCMA的纵向分析确定了累积和最近的身体活动是EAA最强的预测因素.
- 观察到效果的修改,在男性中较强的关联DunedinPACE和西班牙裔GrimAge.
结论:
- 身体活动是与缓慢表观遗传衰老相关的强有力的因素.
- 随着时间的推移,身体活动的积累和最近的活动都是EAA的重要预测因素.
- 这些发现支持身体活动在促进更健康的生物衰老和减轻与年龄相关的健康衰退方面的作用.
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