![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
关于T细胞参与治疗在复发/耐药性惰性非霍奇金淋巴瘤的前景
Max Bakker1,2, Maria T Kuipers1,2, Marie Jose Kersten1,2
1Department of Hematology, Amsterdam UMC Location Vrije Universiteit Medisch Centrum.
Current opinion in oncology
|June 13, 2025
概括
涉及T细胞的疗法,包括化学抗原受体T细胞 (CAR-T) 疗法和双特异性抗体 (BsABs),对复发性/耐火性无力非霍奇金淋巴瘤有前途. 患者因素和可用性指导治疗选择.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 毛囊性淋巴瘤 (FL) 和边缘区域淋巴瘤 (MZL) 是无效的非霍奇金淋巴瘤 (iNHL),具有复发性复发的过程.
- 复发性/耐药性 (r/r) iNHL在治疗选择方面存在挑战.
- 参与T细胞的疗法提供了一种新的治疗方法.
研究的目的:
- 在r/r iNHL中全面评估T细胞参与疗法的疗效和安全性.
- 评估化学抗原受体T细胞 (CAR-T) 治疗和双特异性抗体 (BsABs) 的后勤考虑.
- 在惰非霍奇金淋巴瘤治疗的背景下比较CAR-T和BsABs.
主要方法:
- 在r / rFL和MZL中进行CAR-T治疗的关键临床试验的综述.
- 对各种BsAB的疗效和安全数据的分析.
- 对两种治疗方式的后勤要求和患者特定因素的评估.
主要成果:
- 在r/rFL中,CAR-T疗法显示出高响应率和持久缓解,在MZL中数据有限.
- BsABs在较低的急性毒性方面表现出良好的疗效,但长期使用可能会造成负担.
- 无论是CAR-T还是BsAB都带有长期感染的风险;缺乏直接的比较研究.
结论:
- CAR-T 和 BsAB 是 iNHL 的有前途的治疗方法,具有显著的疗效.
- 治疗决策应根据患者的因素和治疗可用性进行个性化.
- 进一步的后续数据将完善基于证据的FL和MZL管理选择.
相关概念视频
01:27Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
01:22T Cell Activation and Clonal Selection
688
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
688
01:27Cytotoxic T Cells-mediated Immune Response
859
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
859