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婴儿的益生菌用于预防过敏性疾病
Hang Zhen Wang1, Elizabeth H Hayles2, Michelle Fiander3
1Macquarie Medical School, Macquarie University, Sydney, Australia.
益生菌和协生菌在预防喘和湿疹等婴儿过敏疾病方面几乎没有效果. 需要更多的研究来确认婴儿常规使用的益处和安全性.
科学领域:
- 临床免疫学和过敏学
- 微生物组研究的研究.
- 儿科卫生健康 儿科卫生健康
背景情况:
- 过敏性疾病和食物过敏很常见,对健康造成重大负担.
- 益生菌,即殖民肠道的活细菌,已被研究用于过敏预防.
- 这一综述更新了关于预防婴儿过敏的益生菌和共生菌的先前发现.
研究的目的:
- 评估益生菌或共生菌在预防2岁以下婴儿过敏疾病方面的疗效和安全性.
- 为了比较益生菌/共生菌干预与安慰剂或没有治疗.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了多个数据库 (CENTRAL,MEDLINE,Embase) 和试验注册表.
- 包括24个RCT,包括7077对母婴对,重点关注婴儿在最初的六个月.
主要成果:
- 益生菌在预防喘,过敏性鼻炎和IgE介导的牛奶过敏方面几乎没有差异.
- 使用益生菌观察到湿疹的轻微减少,但这与低风险偏差研究不一致.
- 对共生菌和对食物过敏的影响的证据非常不确定;没有报告严重的不良事件.
结论:
- 没有足够的证据支持使用益生菌或共生菌来预防婴儿过敏疾病.
- 虽然没有报告严重的危害,但在例行实施之前需要进一步研究.
- 由于研究在高收入国家普遍存在,研究结果的适用性可能受到限制.
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