在第一个子宫内授精周期中,总的逐步运动精子数量较低的夫妇应该继续接受这种治疗吗?
Zheng Wang1,2,3,4,5, Yuan-Yuan Wang1,2,3,4,5, Shuo Huang1,2,3,4,5
1Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Asian journal of andrology
|June 13, 2025
概括
在第一个子宫内授精 (IUI) 周期洗后的精子计数无法预测第二个IUI周期的活产率,对夫妇有不明原因或轻微的男性不孕不育. 这一发现表明TPMSC不是随后IUI成功的可靠指标.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 不孕症研究 不孕症研究
背景情况:
- 宫内授精 (IUI) 是一种常见的不孕症治疗方法.
- 预测IUI的成功对于患者咨询和治疗计划至关重要.
- 在预测随后的IUI周期中,洗后的累进运动精子总数 (TPMSC) 的作用仍然是研究领域.
研究的目的:
- 调查从第一个IUI周期的洗后TPMSC与第二个IUI周期的怀孕结果之间的关联.
- 确定初始IUI尝试中的TPMSC是否可以预测特定不孕症诊断后续周期的成功.
主要方法:
- 追溯性队列研究分析了8290对夫妇的数据,这些夫妇连续两次IUI循环.
- 情侣有不明原因或轻微的男性因子不孕症,并使用相同的IUI协议.
- 根据第一个IUI周期的洗后TPMSC水平 (×10^6) 将患者分为11组.
主要成果:
- 两组之间没有观察到临床怀孕率或活产率的统计学上显著差异.
- 具体来说,与最低的TPMSC组 (<1 × 10^6) 相比,没有发现任何TPMSC水平和活产率之间的显著关联.
- 第二个IUI周期的活产率在不同的TPMSC组中从5.8%到8.9%不等.
结论:
- 在IUI计划中,对于不明原因和轻微的男性因子不孕症,从第一周期洗后的TPMSC不是第二周期活产率的重要预测因素.
- 临床决策和患者对IUI成功的期望不应该仅仅依赖于最初的TPMSC值.
- 进一步的研究可能会探索这些患者群体IUI结果的其他预测因素.
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