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Updated: Jun 14, 2025

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
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基于LmrR的人造金属酶中的活性增强突变破坏了蛋白质支架的稳定性,并改变了其结构可塑性

Adil A Safeer1, Fabrizio Casilli2, Wouter Beugelink3

  • 1Utrecht University Faculty of Science: Universiteit Utrecht Faculteit Betawetenschappen, Chemistry, NMR section, NETHERLANDS, KINGDOM OF THE.

Chembiochem : a European journal of chemical biology
|June 13, 2025
PubMed
概括

激活人工金属酶 (ArM) 中的突变,如乳球菌多药耐药调节器 (LmrR),通过改变蛋白质动态和基质相互作用来增强催化作用. 这项研究揭示了突变如何改善辅因子保留和可塑性,以实现更高效的反应.

关键词:
这是NMR的NMR.人造金属酶的人造金属酶生物催化剂的生物催化剂酶设计 酶设计蛋白质动力学 蛋白质动力学

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