在决策过程中,侧面轨道前皮层编码了风险的存在和主观风险偏好
Daniel B K Gabriel1, Felix Havugimana2, Anna E Liley3
1Department of Psychiatry, Indiana University School of Medicine, 320 W. 15th St, Indianapolis, IN 46202, United States.
Cerebral cortex (New York, N.Y. : 1991)
|June 13, 2025
概括
侧轨前皮层 (lOFC) 在做决定之前编码环境风险,在做选择时编码奖励大小. 个人风险偏好会影响LOFC如何处理风险和奖励信息.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 行为经济学是一种行为经济学.
背景情况:
- 适应性决策包括评估风险和回报.
- 侧轨前皮层 (lOFC) 参与奖励/惩罚处理和成本/收益分析.
- 对于IOFC在惩罚驱动的风险决策中的具体作用还不清楚.
研究的目的:
- 为了研究侧向轨道前皮层 (lOFC) 活动如何在雄性大鼠中发出风险与安全选项和选择的信号.
- 确定LOFC中惩罚驱动决策的基础的神经机制.
主要方法:
- 雄性老鼠接受了风险决策任务的训练,包括安全奖励与更大的奖励,并有足部冲击惩罚的风险.
- 单个单位在LOFC中的活动是在任务执行期间记录的.
- 机器学习模型被用来分析LOFC活动模式,并预测风险和选择.
主要成果:
- lOFC活动在决策之前编码环境风险,并在行动选择过程中编码奖励大小,独立于风险.
- 机器学习模型准确地预测了LOFC活动的风险,但在预测选择方面效率较低,尽管之前的试验结果提高了准确性.
- 风险偏好性大鼠在LOFC中显示风险编码减少和奖励大小编码增加.
结论:
- 环境风险和奖励信息与主观偏好相结合,以指导风险决策.
- 在LOFC中的神经活动在决策过程中动态地代表了风险和回报的不同方面.
- 风险偏好的个体差异与LOFC神经编码的独特模式有关.
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