评估右心室外流通道的激活延迟,作为布鲁加达综合征的潜在补充诊断工具
Cinzia Monaco1, Ivan Eltsov2, Alvise Del Monte1
1Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, European Reference Networks Guard-Heart, Vrije Universiteit Brussel, Universitair Ziekenhuis, Laarbeeklaan 101, Brussel 1090, Belgium.
概括
这项研究引入了一种新的布鲁加达综合征 (BrS) 诊断方法,使用心电成像 (ECGi) 来识别延迟的右心室外流通道 (RVOT) 激活. 激活时间的45%增加可靠地诊断BrS当心电图是不确定的.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 诊断医学 诊断医学
背景情况:
- 布鲁加达综合征 (BrS) 诊断通常依赖于1型心电图 (ECG) 图案.
- 在一些BrS病例中,标准的心电图解释可能是不确定的,需要使用替代的诊断方法.
研究的目的:
- 开发和验证使用心电成像 (ECGi) 的BrS替代诊断方法.
- 确定在BrS患者中延迟右心室外流通道 (RVOT) 激活的可靠值.
主要方法:
- 这项研究涉及两个阶段:切线确定和使用ECGi参数的验证.
- 在不同心室区域分析了激活时间 (ATm) 和正常化激活时间 (ATm%).
- 基于前右心室 (RV) 和RVOT ATm之间的关系,开发了一个预测模型.
主要成果:
- 与RVOTATm相比,前面RVATm的45%增加被确定为BrS诊断的最佳预测指标 (曲线下的面积=0.97).
- 这一门在第一阶段表现出高准确度 (92%) 和F-score (95%).
- 第2阶段验证显示,模式阳性BrS患者的准确率为96%,隐性BrS患者的准确率为67%.
结论:
- 在RVOT激活的延迟,通过前部-RVATm的45%的增加确定,作为BrS的可靠的诊断标志物.
- 这种基于ECGi的方法在标准ECG诊断无法确定时提供了有价值的工具.
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