呼吸系统症状与一个新的基于叶片的支气管评分系统在一个城市的中国低剂量CT查人口的呼吸系统症状
Zhenhui Nie1, Geertruida H de Bock1, Rozemarijn Vliegenthart2
1Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
在用低剂量CT (LDCT) 查的中国成年人中,超过40%患有支气管切除症,主要发生在肺部下部区域. 较高的支气管评分与喘息增加和胸痛减少相关,这表明它对呼吸系统健康评估具有临床相关性.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 支气管切除症在低剂量CT (LDCT) 肺癌查中经常被发现.
- 在中国人群中,缺乏标准化的,基于叶片的支气管评分系统及其临床相关性,特别是关于呼吸系统症状的临床相关性.
研究的目的:
- 为接受LDCT查的中国城市人口开发基于叶片的支气管评分系统.
- 调查这种支气管评分与呼吸系统症状的存在或不存在之间的关联.
主要方法:
- 来自NELCIN-B3研究的989名中国参与者 (40-74岁) 进行了LDCT查.
- 一个新的评分系统评估了支气管切除症的严重程度和扩展在五个肺叶,包括支气管扩张,气道壁厚度和粘膜损伤.
- 修改后的雷夫分数作为比较值,多变量逻辑回归分析了支气管分数和呼吸系统症状之间的联系.
主要成果:
- 该研究包括44.8%的男性,平均年龄为62岁; 416名参与者患有支气管切除症.
- 轻度支气管扩张和气道壁厚度在右下叶最为普遍.
- 较高的支气管评分与喘息 (OR: 2.35) 有关,与胸痛 (OR: 0.49) 有关.
结论:
- 在中国城市人口中,超过40%的人患有支气管切除症,主要发生在肺部下部.
- 开发的基于叶片的支气管评分系统显示了与喘息的积极关联以及与胸痛的负面关联.
- 这种基于CT的评分系统可以提高肺癌查中的呼吸系统健康评估,促进早期干预.
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