Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

Determination of Renal Drug Clearance: Graphical and Midpoint Methods

87
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
87
Nephrons01:10

Nephrons

2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

62
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
62

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Oral anticoagulation and left atrial appendage closure in dialysis atrial fibrillation: between stroke prevention and bleeding hazard.

Clinical kidney journal·2026
Same author

Causal Effects of Time-Varying Treatments: The G-Formula.

European journal of clinical investigation·2026
Same author

From challenge to innovation: a narrative review on innovation in nephrology and hemodialysis randomized trials.

Journal of nephrology·2026
Same author

Disparity in the regulation and prevention of water versus sodium imbalance in heat-stress nephropathy: a phylogenetic perspective.

Clinical kidney journal·2026
Same author

Beyond the calendar: biologic age as a missing vital sign in chronic kidney disease.

Clinical kidney journal·2026
Same author

Potassium binders as enablers of guideline-directed renin-angiotensin-aldosterone system inhibitor therapy.

Journal of internal medicine·2026

相关实验视频

Updated: Jun 14, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.6K

在病学中进行交叉滞后分析.

Carmine Zoccali1,2,3, Giovanni Tripepi4, Graziella D'Arrigo4

  • 1Renal Research Institute, New York, USA. carmine.zoccali@tin.it.

Journal of nephrology
|June 13, 2025
PubMed
概括

交叉滞后分析揭示了随着时间的推移,健康变量之间的方向联系. 这种统计方法在临床研究中增强了因果推断,特别是在病学中,以了解疾病进展.

关键词:
生物统计学 生物统计学交叉滞后分析 跨滞后分析腎臟病學 (nephrology) 是一種醫學專業.观察性研究是指观察性研究.

更多相关视频

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

521
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.4K

相关实验视频

Last Updated: Jun 14, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.6K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

521
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.4K

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 临床研究 临床研究
  • 统计方法 统计方法

背景情况:

  • 交叉滞后分析检查了变量之间的方向关系随着时间的推移.
  • 这对于理解临床研究中的双向影响至关重要.
  • 该方法有助于解决因果关系问题.

研究的目的:

  • 探索交叉滞后分析在病学中的应用.
  • 调查病和其他健康状况之间的时间关系.
  • 加强因果推断,以了解疾病进展.

主要方法:

  • 使用纵向数据来确定时间优先级.
  • 测试变量之间的相互影响.
  • 对混变量进行控制,以加强因果关系的说法.

主要成果:

  • 交叉滞后分析可以澄清AKI-CKD相互作用,确定AKI是否加速CKD或反之.
  • 它阐明了CKD与心血管疾病的关系,考虑了共同的风险因素.
  • 该方法阐明了脑连接,探索CKD对认知的影响,反之亦然.

结论:

  • 交叉滞后分析为病学中的动态关系提供了一个强大的框架.
  • 它为指导干预和推进疾病机制知识提供了关键的见解.
  • 该方法适应潜在变量和测量误差,以便进行全面分析.