探索长期暴露于颗粒物2.5和甲状腺疾病风险之间的因果关系:孟德尔的随机化分析
Xinyu Su1, Rong Xie1, Wenhuan Li1
1Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
International journal of environmental health research
|June 13, 2025
概括
长期暴露于细颗粒物 (PM2.5) 导致甲状腺疾病的风险增加,特别是自身免疫性甲状腺功能低下症. 减少空气污染对于保护甲状腺健康至关重要.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 遗传流行病学遗传流行病学
背景情况:
- 颗粒物2.5 (PM2.5) 暴露与甲状腺功能障碍有关,但因果证据有限.
- 了解PM2.5对甲状腺健康的因果影响对于公共卫生倡议至关重要.
研究的目的:
- 通过两样本的门德尔随机化方法,研究长期暴露于PM2.5和甲状腺疾病之间的因果关系.
- 为了确定受PM2.5暴露影响的特定甲状腺亚型.
主要方法:
- 作为仪器变量,利用了来自英国生物库的PM2.5暴露相关的遗传变异.
- 采用反变量加权 (IVW) 分析,支持MR-Egger,加权中位数和模式方法,使用FinnGen联盟数据进行甲状腺结果.
- 通过MR-Egger拦截,MR-PRESSO和Cochran的Q测试来评估型和异质性.
主要成果:
- 发现PM2.5暴露与甲状腺疾病风险增加之间存在显著的因果关系 (OR=1.77).
- 自免疫性甲状腺功能低下症与PM2.5暴露有很强的因果关系 (OR=1.83).
- 对于自身免疫性甲状腺功能障碍或其他甲状腺亚型,没有发现显著的因果关系. 灵敏度分析证实没有显著的质性或异质性.
结论:
- 暴露于PM2.5在甲状腺功能障碍的发展中起因作用,特别是自身免疫性甲状腺功能低下症.
- 研究结果强调了减少空气污染的战略对于保护甲状腺健康的重要性.
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