在NAFLD和MAFLD与心血管事件和死亡率之间的比较关联:来自观察性研究的证据
Taoli Fu1, Jitao Ling2, Huilei Zhao2
1Department of Endocrinology, Nanchang People's Hospital, Nanchang, Jiangxi, China.
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和非酒精性脂肪肝疾病 (NAFLD) 会增加心血管风险. 与NAFLD相比,MAFLD似乎具有更高的心血管死亡风险,这表明MAFLD标准可以更好地识别高风险患者.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MAFLD) 与心血管问题有关.
- 与NAFLD与MAFLD相关的确切心血管风险需要进一步澄清.
研究的目的:
- 为了比较被诊断为NAFLD与MAFLD的个体中心血管疾病 (CVD) 事件的风险.
主要方法:
- 使用PubMed,Embase和Cochrane图书馆进行了对队列研究的系统审查和元分析.
- 分析了11项包括11,995,994名患者的队列研究.
- 纽卡斯尔-太华尺度和GRADE方法用于质量评估和证据确定性.
主要成果:
- 无论是NAFLD还是MAFLD,都与心血管事件和因任何原因死亡的风险增加有关.
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与心血管死亡的相关性比NAFLD更强.
- 对大多数结果的证据确定性低至非常低.
结论:
- 无论是NAFLD还是MAFLD都与心血管事件和死亡率的更高风险有关.
- MAFLD标准可以识别比NAFLD标准更有心血管死亡风险的个体.
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