孕期葡萄糖不耐症和儿童和青少年肥胖风险
Jacqueline Maya1,2,3, Carolin C M Schulte4, Sarah Hsu1,5
1Diabetes Unit and Department of Medicine, Massachusetts General Hospital, Boston, MA, United States.
The Journal of clinical endocrinology and metabolism
|June 13, 2025
概括
在怀孕期间暴露于妊娠性葡萄糖不耐症 (GGI) 或妊娠性糖尿病 (GDM) 的儿童面临更高的肥胖风险. 这种风险在老年儿童中仍然存在,即使考虑到母亲的体重指数 (BMI).
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 孕期葡萄糖不耐受 (GGI) 被定义为没有正式妊娠糖尿病诊断的异常葡萄糖查.
- 在子宫内GGI暴露与后代肥胖之间的关联尚未得到一致确立.
- 了解这些风险对于母亲和儿童健康结果至关重要.
研究的目的:
- 调查怀孕期间不同程度的孕产妇血糖和后代肥胖风险之间的关联.
- 根据母亲的葡萄糖耐受性水平,分析不同年龄组 (2-5,6-10,11-18岁) 的肥胖风险.
主要方法:
- 对27,876名儿童进行了回顾性队列研究.
- 分类的孕产妇血糖暴露:正常的葡萄糖耐受性 (NGT),GGI (0或1异常的葡萄糖值) 和妊娠糖尿病 (GDM).
- 使用后勤回归,调整多个孕产妇和婴儿的因素,包括一个模型与第一季度孕产妇的BMI.
主要成果:
- 与NGT相比,暴露于GGI-1和GDM的后代显示肥胖的几率增加.
- 母亲的BMI调整减弱了这种联系,但并没有消除它.
- 暴露于GDM的6-10岁儿童和暴露于GGI-1和GDM的11-18岁儿童仍然存在显著增加的肥胖风险.
结论:
- 在子宫内接触GGI-1和GDM会增加老年儿童和青少年肥胖的风险.
- 这种关联甚至在控制母亲怀孕前的BMI时也存在.
- 强调在怀孕期间控制葡萄糖水平的重要性,以减轻长期后代健康风险.
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