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Updated: Jun 15, 2025

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对ADAM17-iRhom2复合体的激活和抑制的结构见解

Joseph J Maciag1, Conner E Slone1, Hala F Alnajjar1

  • 1Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

Proceedings of the National Academy of Sciences of the United States of America
|June 13, 2025
PubMed
概括

研究人员揭示了ADAM17与iRhom2结合的冷EM结构,详细说明了该复合物如何调节酶活性. 这些发现揭示了与失调的ADAM17 (一种分解蛋白和金属蛋白酶) -17相关的疾病的治疗点.

关键词:
亚当17年 亚当17年一个ectodomain的流失.这就是iRhom2的意义.免疫力是一种免疫力.

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