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Updated: Jun 16, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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AbEpiTope-1.0:通过使用AlphaFold和逆折叠改进了抗体标预测

Joakim Nøddeskov Clifford1, Eve Richardson2, Bjoern Peters2

  • 1Department of Health Technology, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.

Science advances
|June 13, 2025
PubMed
概括

AbEpiTope-1.0使用结构建模和机器学习来预测抗体特定的B细胞表位. 这种新工具提高了针对疫苗和诊断开发的抗体-抗原结合预测准确度.

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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