协同介导的BMP穿模式是类动物中二次身体轴
David Mörsdorf1, Maria Mandela Prünster1, Paul Knabl1,2
1Department of Neurosciences and Developmental Biology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.
Science advances
|June 13, 2025
概括
由Chordin介导的骨形态遗传蛋白 (BMP) 穿,对于海的图案是必不可少的. 这表明BMP穿可能是早期动物建立身体轴的古老机制.
科学领域:
- 发育生物学是发展生物学.
- 进化生物学是进化的生物学.
- 细胞信号传递 细胞信号传递
背景情况:
- 骨形态遗传蛋白 (BMP) 信号建立了双边人的身体轴.
- 协和介导的BMP连接体转移是BMP梯度形成的一个拟议机制.
- 霍丁在类动物中的作用,比如海尼马托斯特拉 (Nematostella),是有争议的:局部抑制剂还是航天飞机?
研究的目的:
- 确定Chordin的细胞外移动性是否是穿的特征,对于Nematostella的模式是必要的.
- 区分霍丁作为局部BMP抑制剂与BMP穿器在类动物中的作用.
主要方法:
- 在Nematostella的Chordin形态背景中生成局部化的Chordin源.
- 评估Chordin细胞外移动性对BMP信号梯度形成的要求.
主要成果:
- 移动协同被认为是建立BMP信号峰值的必要和充分条件.
- 该BMP信号峰形成与本地化Chordin源相对.
- 有证据表明,Chordin 在类动物中作为BMP航天飞机起作用.
结论:
- BMP 穿是双边对称的鱼类内马托斯泰拉的一种功能机制.
- BMP 穿可能代表了 cnidarians 和 bilaterians 的共同祖先的模式形成的祖先机制.
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