Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

291
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
291
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

123
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
123
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

2.8K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
2.8K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

762
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
762

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Probing component segregation and anisotropy for co-deposited glasses of TCTA and Ir(ppy)3 by GIWAXS.

The Journal of chemical physics·2026
Same author

Effect of Surfactants on Posaconazole Crystallization and Polymorphism: Tween 80 vs Span 80.

Crystal growth & design·2025
Same author

High kinetic stability and high density of Ir(ppy)3 doped organic semiconductor glasses.

The Journal of chemical physics·2025
Same author

Structural Evolution in a Glass-Forming Liquid Alcohol by X-Ray Scattering: Contrasting Behaviors of Main Peak and Prepeak Structures.

The journal of physical chemistry. B·2025
Same author

Nanoscale View of Alignment and Domain Growth in a Hexagonal Columnar Liquid Crystal.

ACS nano·2024
Same author

Surface Enrichment and Depletion of Components in a Ternary Drug-Surfactant-Polymer Amorphous Solid Dispersion.

Molecular pharmaceutics·2024

相关实验视频

Updated: Jun 15, 2025

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

19.1K

泥转化:一种用于制备无形固体分散物的一般方法,并完全集成药物和聚合物组件.

Amy Lan Neusaenger1, Caroline Fatina1, Yichun Shen1

  • 1University of Wisconsin, School of Pharmacy, Madison, Wisconsin 53705, United States.

Molecular pharmaceutics
|June 13, 2025
PubMed
概括

泥转化是一种多功能,低成本和绿色的方法,用于为不溶性药物制造无形固体分散 (ASD). 这种技术为传统方法提供了可扩展的替代方案,确保了药物聚合物集成和更好的稳定性.

关键词:
在X射线光电子光谱学中使用X射线光电子光谱.无形药物聚合物盐无形固体分散的无形固体分散盐的形成程度 盐的形成程度聚烯酸) 是一种聚烯酸.泥转换过程中的泥转换

更多相关视频

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.3K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

7.8K

相关实验视频

Last Updated: Jun 15, 2025

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

19.1K
Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography
06:53

Additive Manufacturing of Functionally Graded Ceramic Materials by Stereolithography

Published on: January 25, 2019

14.3K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

7.8K

科学领域:

  • 材料科学 材料科学 材料科学
  • 制药技术 制药技术 制药技术
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 无形固体分散 (ASDs) 增强难溶性药物的可溶性和生物利用性.
  • 传统的ASD制造方法,如热挤出和喷雾干燥具有局限性.
  • 泥转化为ASD制备提供了一种节约溶剂的方法.

研究的目的:

  • 评估泥转化作为一种用于制备18种难溶性药物的无形固体分散剂 (ASD) 的一般方法.
  • 评估药物负载和配方类型 (二元/三元) 对ASD制剂的影响.
  • 为了比较泥转化与传统方法,以提高效率,可扩展性和产品质量.

主要方法:

  • 药物和聚烯酸 (PAA) 的固体混合物在室温下在少量乙醇二甲溶剂中.
  • 在25%和50%的药物负载下准备了ASD.
  • 还制定了含有两种药物的第三级ASD.
  • 该过程被扩大了60倍,以评估工业适用性.

主要成果:

  • 自闭症患者在25%负荷下成功准备了18种药物中的16种,在50%负荷下准备了11种药物.
  • 对于大多数药物来说,泥"清除"表明完全溶解和无形化.
  • 通过溶剂介导的转换导致完全无形的产品,即使没有清算.
  • 通过PAA的药物质子与药物的基本性相关,表明热力学平衡.
  • 组合疗法的第三级ASDs已成功准备好.
  • 缩放到60倍,对产品结构或特性没有任何不良影响.

结论:

  • 泥转化是一种通用,有效和绿色的方法,用于从广泛的难溶性药物中产生ASD.
  • 该方法允许热力学平衡,导致稳定的无形形式.
  • 它适用于二元和三元配方,包括组合疗法.
  • 泥转化是一种可扩展且具有成本效益的替代传统ASD制造技术.